About Us

Zelis is modernizing the healthcare financial experience in the United States (U.S.) across payers, providers, and healthcare consumers. We serve more than 750 payers, including the top five national health plans, regional health plans, TPAs and millions of healthcare providers and consumers across our platform of solutions. Zelis sees across the system to identify, optimize, and solve problems holistically with technology built by healthcare experts – driving real, measurable results for clients.

At Zelis, AI is woven into the fabric of how we work. Every associate is expected - and empowered - to partner with AI to challenge the status quo, accelerate innovation, and amplify their impact. This is a place for builders with a growth mindset who act with agility, embrace change, and use modern technology to shape smarter solutions, exceptional experiences, and the future of our industry for our clients, customers, and our culture.

Why We Do What We Do

In the U.S., consumers, payers, and providers face significant challenges throughout the healthcare financial journey. Zelis helps streamline the process by offering solutions that improve transparency, efficiency, and communication among all parties involved. By addressing the obstacles that patients face in accessing care, navigating the intricacies of insurance claims, and the logistical challenges healthcare providers encounter with processing payments, Zelis aims to create a more seamless and effective healthcare financial system.

Zelis India plays a crucial role in this mission by supporting various initiatives that enhance the healthcare financial experience. The local team contributes to the development and implementation of innovative solutions, ensuring that technology and processes are optimized for efficiency and effectiveness. Beyond operational expertise, Zelis India cultivates a collaborative work culture, leadership development, and global exposure, creating a dynamic environment for professional growth. With hybrid work flexibility, comprehensive healthcare benefits, financial wellness programs, and cultural celebrations, we foster a holistic workplace experience. Additionally, the team plays a vital role in maintaining high standards of service delivery and contributes to Zelis’ award-winning culture.

Position Overview

We are seeking a Microsoft O365 Defender Email & Endpoint Security Engineer to support the design, implementation, and optimization of Microsoft security technologies that protect enterprise email and endpoint environments. This role focuses on engineering, configuration, and continuous improvement of Microsoft Defender for Office 365 and Microsoft Defender for Endpoint to strengthen the organization’s cybersecurity posture.
The ideal candidate will have hands-on experience implementing security controls, tuning detection capabilities, and partnering with security operations teams to improve threat detection and response

Key Responsibilities

Microsoft Defender for Office 365 (Email Security Engineering)

• Implement and maintain Microsoft Defender for Office 365 security policies, including anti-phishing, anti-spoofing, Safe Links, Safe Attachments, and anti-malware protections.

• Configure and optimize email authentication and protection controls such as SPF, DKIM, and DMARC.

• Engineer and tune policies to detect and prevent phishing, business email compromise (BEC), and malicious attachments.

• Develop and maintain email threat protection standards and configurations.

• Partner with Security Operations teams to improve detection rules and remediation workflows.

• Support attack simulation training campaigns and security awareness initiatives.

Microsoft Defender for Endpoint (Endpoint Security Engineering)

• Deploy and configure Microsoft Defender for Endpoint capabilities across enterprise endpoints.

• Implement and manage endpoint security features including:

  • Endpoint Detection & Response (EDR)

  • Attack Surface Reduction (ASR) rules

  • Web and network protection

  • Device control policies

  • Endpoint vulnerability management

• Engineer and maintain endpoint security baselines and hardening standards.

• Tune detection rules and alerts to reduce noise while maintaining strong threat coverage.

• Assist with investigation and remediation of endpoint security incidents when needed.

Platform Engineering & Security Integration

• Integrate Defender solutions with Microsoft Sentinel or other SIEM platforms.

• Develop queries and detection logic using Kusto Query Language (KQL).

• Support automation and response workflows using PowerShell and Microsoft security APIs.

• Maintain documentation for configurations, engineering standards, and operational procedures.

• Collaborate with infrastructure, cloud, and identity teams to implement Zero Trust security controls.

Required Qualifications

• Bachelor’s degree in Cybersecurity, Computer Science, Information Systems, or related field (or equivalent experience).

• 5–7 years of cybersecurity or security engineering experience.

• Hands-on experience with:

  • Microsoft Defender for Office 365

  • Microsoft Defender for Endpoint

  • Microsoft 365 Security & Compliance Center

  • Azure AD / Microsoft Entra ID security features

• Strong understanding of email security technologies (SPF, DKIM, DMARC).

• Experience working with endpoint protection and EDR platforms.

• Familiarity with KQL or similar query languages for threat detection.

• Experience with endpoint management tools such as Intune or SCCM.

Preferred Qualifications

• Microsoft security certifications (SC-200, SC-300, MS-500, or similar).

• Experience integrating Microsoft Defender with Microsoft Sentinel.

• Experience with security automation using PowerShell.

• Knowledge of Zero Trust security architecture.

• Familiarity with vulnerability management tools and processes.

Key Competencies

• Strong technical problem-solving skills

• Ability to design and improve security configurations

• Detail-oriented with strong documentation practices

• Effective collaboration with security operations and infrastructure teams

• Ability to balance security protection with operational usability

Commitment to Diversity, Equity, Inclusion, and Belonging

At Zelis, we champion diversity, equity, inclusion, and belonging in all aspects of our operations. We embrace the power of diversity and create an environment where people can bring their authentic and best selves to work. We know that a sense of belonging is key not only to your success at Zelis, but also to your ability to bring your best each day.

Equal Employment Opportunity

Zelis is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Accessibility Support

We are dedicated to ensuring our application process is accessible to all candidates. If you are a qualified individual with a disability and require reasonable accommodation with any part of the application and/or interview process, please email talentacquisition@zelis.com.